Minority Health Archive

Depressive Symptoms, Race, and Glucose Concentrations

BOYLE, STEPHEN H. and SURWIT, RICHARD S. and GEORGIADES, ANASTASIA and BRUMMETT, BEVERLY H. and HELMS, MICHAEL J. and WILLIAMS, REDFORD B. and BAREFOOT, JOHN C. (2007) Depressive Symptoms, Race, and Glucose Concentrations. Diabetes Care, 30 (10). pp. 2484-2488.

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OBJECTIVE— This study examined the associations of depressive symptoms with glucose concentrations and morning cortisol levels in 665 African-American and 4,216 Caucasian Vietnam- era veterans. RESEARCH DESIGN AND METHODS— Glucose level was measured as a three-level variable (diabetes, impaired glucose, and normal). Depressive symptoms were measured by the Obvious Depression Scale (OBD) from the Minnesota Multiphasic Personality Inventory. RESULTS— Regression models showed significant race OBD interactions in relation to glucose concentration (P 0.0001) and cortisol (P 0.0001). The OBD was positively associated with glucose concentration and cortisol in both racial groups. However, the magnitude of those associations was larger for African Americans. Further analyses suggested that cortisol partially mediated the race difference in the relation of depressive symptoms to glucose concentrations. CONCLUSIONS— These results suggest that enhanced hypothalamic pituitary adrenal activity plays an important role in the relation of depressive symptoms to dysregulated glucose metabolism and may partially explain the differential effects of depressive symptoms on glucose levels in African-American and Caucasian male subjects.

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Item Type: Article
Additional Information: Access to full text is subject to the publisher's access restrictions.
Uncontrolled Keywords: depressive symptoms; glucose concentrations; Obvious Depression Scale; African Americans; diabetes
Subjects: Health
Health > Public Health > Chronic Illness & Diseases > Diabetes
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Depositing User: Users 141 not found.
Date Deposited: 10 Feb 2008
Last Modified: 11 May 2011 13:40
Link to this item (URI): http://health-equity.lib.umd.edu/id/eprint/881

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