Minority Health Archive

Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men

Freedman, Matthew L. and Haiman, Christopher A. and Patterson, Nick and McDonald, Gavin J. and Tandon, Arti and Waliszewska, Alicja and Penney, Kathryn and Steen, Robert G. and Kristin Ardlie, Kristin and John, Esther M. and Oakley-Girvan, Ingrid and Whittemore, Alice S. and Cooney, Kathleen A. and Ingles, Sue A. and Altshuler, David and Henderson, Brian E. and Reich, David (2006) Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. PNAS, 103 (38). pp. 14068-14073.

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Abstract

A whole-genome admixture scan in 1,597 African Americans identified a 3.8Mbinterval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD)7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age (P < 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate cancer in African Americans is greatest in younger men (and attenuates with older age). The same region was recently identified through linkage analysis of prostate cancer, followed by fine-mapping. We strongly replicated this association (P<4.2109) but find that the previously described alleles do not explain more than a fraction of the admixture signal. Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it.


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Item Type: Article
Additional Information: Access to full text is subject to the publisher's access restrictions.
Uncontrolled Keywords: prostate cancer locus, prostate cancer, increased risk, African Americans, risk gene, genetic risk variants, admixture mapping
Subjects: Health > Public Health > Chronic Illness & Diseases
Health > Public Health > Chronic Illness & Diseases > Cancer
Research > Genetics and Race
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Depositing User: Users 141 not found.
Date Deposited: 03 Apr 2011
Last Modified: 19 May 2011 16:58
Link to this item (URI): http://health-equity.lib.umd.edu/id/eprint/768

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