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The Relation of Diabetes, Impaired Fasting Blood Glucose, and Insulin Resistance to Left Ventricular Structure and Function in African Americans: The Jackson Heart Study

Fox, E. R. and Sarpong, D. F. and Cook, J. C. and Samdarshi, T. E. and Nagarajarao, H. S. and Liebson, P. R. and Sims, M. and Howard, G. and Garrison, R. and Taylor, H. A. (2011) The Relation of Diabetes, Impaired Fasting Blood Glucose, and Insulin Resistance to Left Ventricular Structure and Function in African Americans: The Jackson Heart Study. Diabetes Care, 34 (2). pp. 507-509. ISSN 0149-5992

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Abstract

OBJECTIVE We assessed the relation of diabetes and insulin resistance (IR) on left ventricular (LV) structure and function in African Americans. RESEARCH DESIGN AND METHODS Among those receiving echocardiograms in cycle 1 of the Jackson Heart Study, we assessed the sex-specific relation of fasting blood glucose (FBG), diabetes, and IR to LV structure and function, adjusting for age, systolic blood pressure, antihypertensive medications, and BMI. RESULTS Among 2,399 participants, LV mass index (Pwomen = 0.0002 and Pmen = 0.02), posterior wall thickness (Pwomen = 0.01 and Pmen = 0.05), and interventricular septal wall thickness (Pwomen = 0.01) were related to FBG categories. Among those with normal FBG and no diabetes, concentric remodeling and low ejection fraction in women and LV mass index and posterior wall thickness in men were related to IR. CONCLUSIONS In the largest study of its kind in a community-based cohort of African Americans, we found a relation of FBG category and IR to LV structure and function.


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Item Type: Article
Additional Information: This article is available at the publisher’s Web site. Access to the full text is subject to the publisher’s access restrictions.
Uncontrolled Keywords: diabetes, insulin resistance, African Americans, Jackson Heart Study
Subjects: Health > Public Health > Chronic Illness & Diseases > Diabetes
Research
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Depositing User: Users 141 not found.
Date Deposited: 14 Aug 2011 12:43
Last Modified: 14 Aug 2011 12:43
Link to this item (URI): http://health-equity.lib.umd.edu/id/eprint/3048

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