Minority Health Archive

Complex HLA-DR and -DQ Interactions Confer Risk of Narcolepsy-Cataplexy in Three Ethnic Groups

Mignot, Emmanuel and Lin, Ling and Rogers, William and Honda, Yutaka and Qiu, Xiaohong and Lin, Xiaoyan and Okun, Michele and Hohjoh, Hirohiko and Miki, Tetsuro and Hsu, Susan H and Leffell, Mary S and Grumet, F Carl and Fernanandez-Vina, Marcelo (2001) Complex HLA-DR and -DQ Interactions Confer Risk of Narcolepsy-Cataplexy in Three Ethnic Groups. American Journal of Human Genetics, 68. pp. 686-699.

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Abstract

Human narcolepsy-cataplexy, a sleep disorder associated with a centrally mediated hypocretin (orexin) deficiency, is tightly associated with HLA-DQB1*0602. Few studies have investigated the influence that additional HLA class II alleles have on susceptibility to this disease. In this work, 1,087 control subjects and 420 narcoleptic subjects with cataplexy, from three ethnic groups, were HLA typed, and the effects of HLA-DRB1, -DQA1, and -DQB1 were analyzed. As reported elsewhere, almost all narcoleptic subjects were positive for both HLA-DQA1*0102 and -DQB1*0602. A strong predisposing effect was observed in DQB1*0602 homozygotes, across all ethnic groups. Relative risks for narcolepsy were next calculated for heterozygous DQB1*0602/other HLA class II allelic combinations. Nine HLA class II alleles carried in trans with DQB1*0602 were found to influence disease predisposition. Significantly higher relative risks were observed for heterozygote combinations including DQB1*0301, DQA1*06, DRB1*04, DRB1*08, DRB1*11, and DRB1*12. Three alleles—DQB1*0601, DQB1*0501, and DQA1*01 (non-DQA1*0102)—were found to be protective. The genetic contribution of HLA-DQ to narcolepsy susceptibility was also estimated by use of gamma statistics. Results indicate that complex HLA-DR and -DQ interactions contribute to the genetic predisposition to human narcolepsy but that additional susceptibility loci are also most likely involved. Together with the recent hypocretin discoveries, these findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy.


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Item Type: Article
Additional Information: This article is available at the publisher’s Web site. Access to the full text is subject to the publisher’s access restrictions.
Uncontrolled Keywords: Human narcolepsy-cataplexy, sleep disorder, hypocretin (orexin) deficiency, Japanese, African Americans, blacks, White Americans, whites, caucasians
Subjects: Health
Research
Research > studies
Research > Genetics and Race
Related URLs:
    Depositing User: Kismet Loftin-Bell
    Date Deposited: 30 Sep 2005
    Last Modified: 14 Jul 2011 14:27
    Link to this item (URI): http://health-equity.lib.umd.edu/id/eprint/259

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