Minority Health Archive

A High-Density Admixture Map for Disease Gene Discovery in African Americans

Smith, Michael W and Patterson, Nick and Lautenberger, James A and Truelove, Ann L and McDonald, Gavin J and Waliszewska, Alicja and Kessing, Bailey D and Malasky, Micahel J and Scafe, Charles and Le, Ernest and De Jager, Philip L and Mignault, Andre A and Yi, Zeng and de The, Guy and Essex, Myron and Sankale, Jean-Louis and Moore, Jason H and Poku, Kwabena and Phair, John P and Goedert, James J and Vlahov, David and Williams, Scott M and Tishkoff, Sarah A and Winkler, Cheryl A and De La Vega, Francisco M and Woodage, Trevor and Sninsky, John J and Hafler, David A and Altshuler, David and Gilbert, Dennis A and O'Brien, Stephen J and Reich, David (2004) A High-Density Admixture Map for Disease Gene Discovery in African Americans. American Journal of Human Genetics, 74 (5). pp. 1001-1013.

Full text not available from this repository.

Abstract

Admixture mapping (also known as “mapping by admixture linkage disequilibrium,” or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans, with ∼100 times fewer markers than are required for whole-genome haplotype scans. However, it has not been possible to perform powerful scans with admixture mapping because the method requires a dense map of validated markers known to have large frequency differences between Europeans and Africans. To create such a map, we screened through databases containing ∼450,000 single-nucleotide polymorphisms (SNPs) for which frequencies had been estimated in African and European population samples. We experimentally confirmed the frequencies of the most promising SNPs in a multiethnic panel of unrelated samples and identified 3,011 as a MALD map (1.2 cM average spacing).We estimate that this map is ∼70% informative in differentiating African versus European origins of chromosomal segments. This map provides a practical and powerful tool, which is freely available without restriction, for screening for disease genes in African American patient cohorts. The map is especially appropriate for those diseases that differ in incidence between the parental African and European populations.


Export/Citation:EndNote | BibTeX | Dublin Core | ASCII (Chicago style) | HTML Citation | OpenURL | Reference Manager
Social Networking:

Item Type: Article
Additional Information: This article is available at the publisher’s Web site. Access to the full text is subject to the publisher’s access restrictions.
Uncontrolled Keywords: admixture mapping, African Americans, genetics, genes
Subjects: Health > Public Health > Chronic Illness & Diseases
Research
Research > Genetics and Race
Related URLs:
Depositing User: Kismet Loftin-Bell
Date Deposited: 17 Aug 2005
Last Modified: 24 Jun 2011 12:54
Link to this item (URI): http://health-equity.lib.umd.edu/id/eprint/163

Actions (login required)

View Item