Minority Health Archive

ROLE OF THIAZOLIDINEDIONES IN THE MANAGEMENT OF TYPE 2 DIABETES: FOCUS ON ETHNIC MINORITY POPULATIONS

Umpierrez, Guillermo and Dagogo-Jack, Samuel (2006) ROLE OF THIAZOLIDINEDIONES IN THE MANAGEMENT OF TYPE 2 DIABETES: FOCUS ON ETHNIC MINORITY POPULATIONS. Ethnicity & Disease, 16 (1). pp. 51-57. ISSN 1049-510X

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Abstract

Persons from ethnic minority populations in the United States suffer disproportionately more from type 2 diabetes and its complications than do Caucasians. Genetic and acquired factors likely contribute to the ethnic disparities of type 2 diabetes. The pathophysiologic hallmarks consist of insulin resistance, progressive pancreatic b-cell dysfunction, and excessive hepatic glucose production. The ideal treatment for type 2 diabetes should correct insulin resistance and b-cell dysfunction; and normalize hepatic glucose output; and prevent, delay, or reverse diabetic complications. The discovery of a new class of drugs, thiazolidinediones, has provided an effective tool to correct key underlying defects in type 2 diabetes. Thiazolidinediones improve insulin sensitivity and have beneficial effects on pancreatic b-cell function and hepatic glucose production. Furthermore, their potent insulin-sensitization effect predicts that treatment with thiazolidinediones will improve cardiovascular risk factors, including lipid profile, fibrinolysis, endothelial function, and atheroinflammatory markers. These benefits are expected to be particularly important among ethnic minority patients who tend to have greater insulin resistance than do Caucasians.


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Item Type: Article
Additional Information: After clicking link, scroll down the page to find the article.
Uncontrolled Keywords: Thiazolidinediones; Diabetes
Subjects: Health > Disparities
Health > Public Health > Chronic Illness & Diseases > Diabetes
Research > Genetics and Race
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Depositing User: Users 141 not found.
Date Deposited: 11 Dec 2008
Last Modified: 02 Jun 2011 10:01
Link to this item (URI): http://health-equity.lib.umd.edu/id/eprint/1239

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