Minority Health Archive

HYPERTENSION, TYPE 2 DIABETES, AND BLOOD GROUPS IN A POPULATION OF AFRICAN ANCESTRY

Nemesure, Barbara and Wu, Suh-Yuh and Hennis, Anselm and Leske, M. Cristina (2006) HYPERTENSION, TYPE 2 DIABETES, AND BLOOD GROUPS IN A POPULATION OF AFRICAN ANCESTRY. Ethnicity & Disease, 16 (4). pp. 822-829. ISSN 1049-510X

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Abstract

Objective: To evaluate the possible relationship of hypertension and diabetes with the ABO, Rhesus, and Duffy blood groups, which are known markers of African ancestry. Design: Population-based study. Setting and Participants: A random sample of 1253 Barbados residents, $40 years of age. Main Outcome Measures: Hypertension was defined as a systolic blood pressure .140 mm Hg or a diastolic blood pressure .90 mm Hg or use of antihypertensive treatment; type 2 diabetes was defined as a glycosylated hemoglobin level .10% and/or a history of treatment in those .30 years of age. Results: In logistic regression analyses, elevated diastolic blood pressure was positively associated with years of age (odds ratio [OR] 1.03, 95% confidence interval CI 1.02–1.05), the Rhesus D+ antigen (OR 2.68, 95% CI 1.21–5.97) and body mass index (OR 1.53, 95% CI 1.19–1.96), but negatively associated with the ABO blood group A allele (OR 0.68, 95% CI .48–.97). A separate logistic regression model indicated that the likelihood of diabetes increased with years of age (OR 1.03, 95% CI 1.01–1.04), hypertension (OR 1.56, 95% CI 1.10–2.20), body mass index (OR 1.68, 95% CI 1.29–2.20), and waist-hip ratio (OR 1.36, 95% CI 1.05–1.75), but decreased with presence of the Rhesus C+ antigen (OR .66, 95% CI .44–.97). Conclusions: The associations of diabetes and hypertension to these blood groups support possible genetic influences on both conditions in this and similar African-origin populations; however, further investigations in other settings are necessary to more fully elucidate these findings.


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Item Type: Article
Additional Information: After clicking on the link, scroll down the page to find the article.
Uncontrolled Keywords: Duffy and Rhesus Blood Groups; ABO; Blood Pressure; Diabetes
Subjects: Health > Public Health > Chronic Illness & Diseases > Diabetes
Health > Public Health > Chronic Illness & Diseases > Hypertension
Research
Research > Genetics and Race
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Depositing User: Users 141 not found.
Date Deposited: 08 Dec 2008
Last Modified: 29 May 2011 20:18
Link to this item (URI): http://health-equity.lib.umd.edu/id/eprint/1194

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